Ageing is associated with a decline in autophagy and elevated reactive oxygen species (ROS), which can breach the capacity of antioxidant systems. Resulting oxidative stress can cause further cellular damage, including DNA breaks and protein misfolding. This poses a challenge for longevous organisms, including humans. In this review, we hypothesise that in the course of human evolution selective autophagy receptors (SARs) acquired the ability to sense and respond to localised oxidative stress. We posit that in the vicinity of protein aggregates (...) and dysfunctional mitochondria oxidation of key cysteine residues in SARs induces their oligomerisation which initiates autophagy. The degradation of damaged cellular components thus could reduce ROS production and restore redox homeostasis. This evolutionarily acquired function of SARs may represent one of the biological adaptations that contributed to longer lifespan. Inversely, loss of this mechanism can lead to age‐related diseases associated with impaired autophagy and oxidative stress. (shrink)

Anticipating the ethical impact of emerging technologies is an essential part of responsible innovation. One such emergent technology is the digital twin which we define here as a living replica of a physical system (human or non-human). A digital twin combines various emerging technologies such as AI, Internet of Things, big data and robotics, each component bringing its own socio-ethical issues to the resulting artefacts. The question thus arises which of these socio-ethical themes surface in the process and how they (...) are perceived by stakeholders in the field. In this report we present the results of a qualitative study into the socio-ethical benefits and socio-ethical risks of using digital twins in healthcare. Employing insights from ethics of technology and the Quadruple Helix theory of innovation, we conducted desk research of white literature and 23 interviews with representatives from the four helixes: industry, research, policy and civil society. The ethical scan revealed several important areas where the digital twin can produce socio-ethical value (e.g., prevention and treatment of disease, cost reduction, patient autonomy and freedom, equal treatment) but also several important areas of socio-ethical risks (e.g., privacy and property of data, disruption of existing societal structures, inequality and injustice). We conclude with a reflection on the employed analytical tool and suggestions for further research. (shrink)

South African law has traditionally denied property sharing rights to people in non-marital intimate partnerships, but a series of new cases has created the possibility of enforcing universal partnership contracts to claim a share in partnership property. However, evidential biases within these progressive cases reflect a historical disdain for women’s contributions to relationships and a widespread reluctance to believe women’s testimony about the existence of agreements to share. These biases bear strong resemblances to the gender stereotypes which have been the (...) subject of feminist critique in rape law. Central to both rape and universal partnerships is the issue of consent or agreement between men and women. This, in turn, depends on social beliefs about male and female entitlements in the realms of sex and intimate relationships. The paper highlights the commonalities and parallels between the legal treatment of women’s evidence about the existence of contracts on the one hand, and the prejudice faced by complainants in rape cases. (shrink)

In 2002 the constitutionality of the Sexual Offences Act, which criminalizes the behaviour of sex workers but fails to punish their clients, was at issue in the South African Constitutional Court. The majority of the Court held that the legislation does not constitute indirect discrimination on the basis of gender. The minority judgment found indirect gender discrimination, but held that the legislation did not infringe upon sex workers’ rights to dignity and privacy. This note argues that the reasoning in both (...) the majority and minority judgments reflects and contributes to detrimental stereotypes of feminine sexuality, which, in turn, exacerbate women’s vulnerability to H.I.V. infection in South Africa. (shrink)

Although the obligation to appoint women as judges originates from the constitutional injunction to consider “the need for the judiciary to reflect broadly the racial and gender composition of South Africa,” gender transformation has lagged behind racial transformation of the bench. During the past four years, however, the lack of women appointees has become a more contested issue. This paper investigates the relationship between gender transformation and racial transformation of the judiciary in public debates around the judiciary. Despite the universally (...) voiced concern about the lack of women judges, the most frequent and acrimonious public disputes continue to centre upon racial issues. The imperative to appoint women judges is often articulated as an alternative to appointing black judges, although the statistics show that the greatest need is for the appointment of black African women. Debates on gender transformation of the bench also remain premised on a formal notion of equality that focuses on numbers of women judges rather than on appointing male or female judges who are committed to challenging gender oppression. This means that the entrenched professional cultures, norms and structures that benefit men are left unchallenged. (shrink)

The main issue in the Masiya judgment was whether the current South African definition of rape—namely non-consensual penetration of a vagina by a penis—should be extended to include anal penetration of both female and male victims. The majority of the Constitutional Court held that anal penetration of female victims should constitute rape, but declined to offer similar protection to male victims. This note argues that this judgment reverts to and reinforces patriarchal stereotypes and dichotomies and that it misunderstands, in a (...) profound way, central concepts such as sex and gender and the gendered nature of rape. It further suggests that, instead of being an aberration, the judgment actually fits into a pattern of conservative judgments about gender and sexuality by the South African Constitutional Court. (shrink)

Although the academic interest in ethical mutual fund performance has developed steadily, the evidence to date is mainly sample-specific. To tackle this critique, new research should extend to unexplored countries. Using this as a motivation, we examine the performance and risk sensitivities of Canadian ethical mutual funds vis-à-vis their conventional peers. In order to overcome the methodological deficiencies most prior papers suffered from, we use performance measurement approaches in the spirit of Carhart (1997, Journal of Finance 52(1): 57–82) and Ferson (...) and Schadt (1996, Journal of Finance 51(2): 425–461). In doing so, we investigate the aggregated performance and investment style of ethical and conventional mutual funds and allow for time variation in the funds’ systematic risk. Our␣Canadian evidence supports the conjecture that any␣performance differential between ethical mutual funds and their conventional peers is statistically insignificant. (shrink)

This book explores the concept of Knowing God and the Knowability of God from an interdisciplinary theological perspective. Approaching the issue from the perspectives of their respective theological disciplines, contributors reflect on what it means to know God, how people of faith have sought to know God in the past, and indeed whether, and to what extent, such knowledge is even possible.

The jaw mechanism of cichlid fishes is an intricate apparatus with complex force transmission from muscles to environment. The proportions of this apparatus change considerably during growth mainly due to scale effects. In adult fishes, the proportions differ, corresponding with the type of preferred food. In such a complex mechanism, it is very hard to gain insight into the functional meaning of the differences in proportions, unless a biomechanical model is constructed, describing kinematics and force equilibria of the apparatus.Such a (...) model has been constructed and by means of perturbation analysis anatomical points could be selected of which the positions are very important for the function of biting. These hot spots need only small displacements in order to obtain an increase in biting force. By means of a newly developed mathematical technique, it was possible to move the anatomical points in very small steps towards more favourable positions for the function of biting. (shrink)

994 JOURNAL OF THE HISTORY OF PHILOSOPHY 34:2 APRIL i996 Gregory Schufreider. Confessions of a Rational Mystic: anselm's Early Writings. West Lafa- yette, IN: Purdue University Press, i993. Pp. 392. Cloth, $39.95- Paper, $15.95. In his Confessions ofa RationalMystic, Gregory Schufreider sets out to explain Anselm to a modern audience, while remaining loyal to the philosophical and theological outlook of his premodern author. Schufreider succeeds remarkably well in the first part of his task, as he explains Anselm's argument to an (...) audience unfamiliar with its historical context: medieval monastic life. To overcome the distance between Anselm and his modern audi- ence, Schufreider introduces four meaningful approaches to the interpretation of a text: the logical, the hermeneutical, the phenomenological and the deconstructive . Critical of the ahistorical rationality implicit in the logical approach to Anselm's "ontological" argument,.. (shrink)

This article takes its starting‐point in the current resurgence of interest in negative theology. Being especially prevalent among postmodern thinkers, this interest coincides with a strong conviction concerning the absence of the divine. In the postmodern context the interest in negative theology leads quite naturally into a debate on negative anthropology, as humanity's increasing awareness of its own finitude appears to reflect a similar break with the metaphysics of being.To analyze the tradition of negative theology, the article goes back to (...) its prime architect, Pseudo‐Dionysius . By comparing him to an author who preceded him, viz. Augustine, and one who followed him, viz. Eriugena, the article aims at giving a ‘thicker’ description of his position by framing it historically. In doing so it draws two conclusions. It first shows that the connection between negative theology and negative anthropology is indeed Dionysian; as such it is rightfully pointed to in postmodern thought. In contradistinction to postmodern applications, however, Dionysius' interest in negativity is shown to reflect before all a desire to wrestle with the overpowering presence of the divine instead of concluding to its absence. (shrink)

This article takes its starting‐point in the current resurgence of interest in negative theology. Being especially prevalent among postmodern thinkers, this interest coincides with a strong conviction concerning the absence of the divine. In the postmodern context the interest in negative theology leads quite naturally into a debate on negative anthropology, as humanity's increasing awareness of its own finitude appears to reflect a similar break with the metaphysics of being.To analyze the tradition of negative theology, the article goes back to (...) its prime architect, Pseudo‐Dionysius. By comparing him to an author who preceded him, viz. Augustine, and one who followed him, viz. Eriugena, the article aims at giving a ‘thicker’ description of his position by framing it historically. In doing so it draws two conclusions. It first shows that the connection between negative theology and negative anthropology is indeed Dionysian; as such it is rightfully pointed to in postmodern thought. In contradistinction to postmodern applications, however, Dionysius' interest in negativity is shown to reflect before all a desire to wrestle with the overpowering presence of the divine instead of concluding to its absence. (shrink)

Résumé L’article propose une analyse comparative de la pensée mystique de Jean Scot Érigène (810-877) et de Maître Eckhart (1260-1328). Nuançant les critiques contemporaines relatives au rôle joué par l’expérience dans le mysticisme médiéval, il défend la position selon laquelle il est préférable d’instaurer une comparaison sémantique détaillée de la pensée de ces deux auteurs plutôt que de diviser le mysticisme médiéval en fonction de l’influence mystique augustinienne ou dionysienne décelable chez chacun d’entre eux. L’auteure mène une telle analyse en (...) se reposant sur l’utilisation du concept d’incarnation comme principe sémantique fécond et non comme doctrine théologique. Tandis qu’Érigène utilise ce concept pour engager la conversation avec le divin (utilisation « horizontale »), Eckhart s’en sert pour donner naissance à une vision mystique plus incisive (utilisation « verticale »). Nuançant également l’idée selon laquelle l’apophase est une caractéristique commune de la tradition néoplatonicienne médiévale, l’auteure montre qu’Érigène et Eckhart utilisent l’apophase pour obtenir des effets fort différents. Guidés par leur désir de percer tout mécanisme de la contemplation mystique sans pour autant discréditer l’expérience en tant que telle, Érigène et Eckhart ne conçoivent pas l’apophase en contradiction avec la corporalité, mais l’utilisent pour affirmer l’ordre sous-jacent et le caractère commun de la nature et de la vie. (shrink)

The logical connection argument claims that since the relation between a want and the supposedly resultant action is " logical " in nature, Whereas the relation between any cause and its effect must be contingent in nature, A want therefore cannot be the cause of an action. I consider four classical formulations of the lca, And review various objections that have been brought against them. Then I present my own formulation of the lca, Which is immune to such objections. I (...) conclude that we must abandon the idea that a person's wants cause his actions. (shrink)

This book deals with Eriugena's view of man in the context of his thinking on universal nature.

Ethicists differ considerably in their reasons for using empirical data. This paper presents a brief overview of four traditional approaches to the use of empirical data: “the prescriptive applied ethicists,” “the theorists,” “the critical applied ethicists,” and “the particularists.” The main aim of this paper is to introduce a fifth approach of more recent date (i.e. “integrated empirical ethics”) and to offer some methodological directives for research in integrated empirical ethics. All five approaches are presented in a table for heuristic (...) purposes. The table consists of eight columns: “view on distinction descriptive-prescriptive sciences,” “location of moral authority,” “central goal(s),” “types of normativity,” “use of empirical data,” “method,” “interaction empirical data and moral theory,” and “cooperation with descriptive sciences.” Ethicists can use the table in order to identify their own approach. Reflection on these issues prior to starting research in empirical ethics should lead to harmonization of the different scientific disciplines and effective planning of the final research design. Integrated empirical ethics (IEE) refers to studies in which ethicists and descriptive scientists cooperate together continuously and intensively. Both disciplines try to integrate moral theory and empirical data in order to reach a normative conclusion with respect to a specific social practice. IEE is not wholly prescriptive or wholly descriptive since IEE assumes an interdepence between facts and values and between the empirical and the normative. The paper ends with three suggestions for consideration on some of the future challenges of integrated empirical ethics. (shrink)

OGHRA is an international and interdisciplinary enterprise on the impact of Augustine of Hippo. With contributions from over 400 international experts, it offers a detailed introduction and 600 entries which describe, analyse, and evaluate Augustine's influence on a broad variety of key historical figures and themes through the ages.

This volume contains essays by twenty-two eminent scholars from across North America and Europe, examining various aspects of the Hebraic, Hellenic, patristic, medieval, and early modern understandings of God and creation.

This book presents a study of twelfth-century humanism seen as an all-embracing discourse in which the human and the divine interact on equal terms. The book focuses on a number of twelfth-century intellectuals, especially Thierry of Chartres, Peter Abelard, William of Conches, Bernard Silvestris, and Alan of Lille. Defining characteristic of their texts is the fact that God, nature and humanity enter into a trialogue of sorts involving many disparate subjects and aiming to bring out the archetypal relatedness of all (...) kinds of knowledge with respect to human nature. As the authors studied here engage the divine and the universe in a joint conversation, the book ultimately concentrates on trying both to understand its appeal and to explain its subsequent demise. (shrink)